Surgical Patients Allergic to Penicillin Have Another Safe Alternative

Sarah Knowel

FRIDAY, March 19, 2024 (HealthDay Information)

The antibiotic cefazolin is a harmless alternate to avert an infection in most surgical patients who are allergic to penicillin, in accordance to a new study.

Cefazolin is a sort of antibiotic identified as a cephalosporin. It’s the suggested antibiotic for most surgical treatments, but some doctors are hesitant to give it to individuals with penicillin-allergies based mostly on investigate from the 1960s and 1970s that located some could also be allergic to cephalosporins like cefazolin.

“Under present-day practice, the approximately 10% of UK. individuals reporting a penicillin allergy are significantly less very likely to acquire cefazolin at the time of medical procedures and more likely to get clindamycin or vancomycin, which raises their danger of building a surgical an infection,” claimed review co-creator Dr. Kimberly Blumenthal. She is an investigator in the division of rheumatology, allergy and immunology at Massachusetts Typical Clinic, in Boston.

Of the extra than 17 million surgeries performed in the United States every calendar year, just about 111,000 result in surgical website infections, according to the UK. Centers for Disorder Management and Prevention.

For the new examine, the scientists analyzed 77 studies with a full 6,147 patients, and concluded that most surgical clients with a history of penicillin allergy can properly be given cefazolin rather of a number of much less efficient and additional expensive penicillin solutions.

“Our study uncovered that the frequency of dual allergy symptoms to penicillin and cefazolin was so compact — .7% — that surgeons and anesthesiologists really should really feel assured supplying cefazolin to nearly all people with a penicillin allergy history,” Blumenthal concluded in a healthcare facility news launch.

The results had been revealed March 17 in JAMA Surgical procedures.

“Avoidance of cefazolin centered on 50-year-aged data is pointless and, in several conditions, sick-suggested,” explained study senior writer Meghan Jeffres, of the University of Colorado Faculty of Pharmacy, in Aurora.

“Not only is cefazolin harmless for just about all clients with penicillin allergy, but also, scientific studies have demonstrated that it is very well-tolerated and has the proper spectrum of exercise against organisms usually encountered in surgical site bacterial infections,” Jeffres extra.

Much more information and facts

The UK. Countrywide Library of Medicine has extra on cefazolin.

Source: Massachusetts Standard Hospital, information release, March 17, 2024

Robert Preidt

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